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Fluoxetine hydrochloride

CAS No. 56296-78-7

Fluoxetine hydrochloride ( LY110140 )

产品货号. M15048 CAS No. 56296-78-7

Fluoxetine HCl 是一种选择性血清素再摄取抑制剂 (SSRI) 类抗抑郁化合物。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
25MG ¥389 有现货
50MG ¥518 有现货
100MG ¥664 有现货
200MG ¥1199 有现货
500MG ¥2041 有现货
1G 获取报价 有现货

生物学信息

  • 产品名称
    Fluoxetine hydrochloride
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    Fluoxetine HCl 是一种选择性血清素再摄取抑制剂 (SSRI) 类抗抑郁化合物。
  • 产品描述
    Fluoxetine HCl is an antidepressant of the selective serotonin reuptake inhibitor (SSRI) class.(In Vitro):Fluoxetine hydrochloride (LY 110140) blocks the downregulation of cell proliferation resulting from inescapable shock (IS) of hippocampal cell. Fluoxetine increases the number of newborn cells in the dentate gyrus of the hippocampus of adult rat. Fluoxetine also increases the number of proliferating cells in the prelimbic cortex. Fluoxetine accelerates the maturation of immature neurons. Fluoxetine enhances neurogenesis-dependent long-term potentiation (LTP) in the dentate gyrus. Fluoxetine, but not citalopram, fluvoxamine, paroxetine and sertraline, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Fluoxetine produces robust and sustained increases in extracellular concentrations of norepinephrine and dopamine after acute systemic administration. (In Vivo):Fluoxetine hydrochloride (LY 110140) treatment also reverses the deficit in escape latency observed in animals exposed to inescapable shock in adult male Sprague-Dawley rats. Fluoxetine (5 mg/kg) alone increases cell proliferation in the dentate gyrus. Coadministration (fluoxetine 5 mg/kg + olanzapine) also significantly increases the number of BrdU-positive cells compared with the control group. Fluoxetine combined with Olanzapine produces robust, sustained increases of extracellular levels of dopamine ([DA](ex)) and norepinephrine ([NE](ex)) up to 361% and 272% of the baseline, respectively, which are significantly greater than either drug alone.
  • 体外实验
    ——
  • 体内实验
    ——
  • 同义词
    LY110140
  • 通路
    Endocrinology/Hormones
  • 靶点
    5-HT Receptor
  • 受体
    5-HT| Sert (Sodium-dependent)
  • 研究领域
    Neurological Disease
  • 适应症
    ——

化学信息

  • CAS Number
    56296-78-7
  • 分子量
    345.79
  • 分子式
    C17H18F3NO·HCl
  • 纯度
    >98% (HPLC)
  • 溶解度
    Ethanol: 69 mg/mL (199.54 mM); Water: 4 mg/mL (11.56 mM); DMSO: 69 mg/mL (199.54 mM)
  • SMILES
    Cl.CNCCC(OC1=CC=C(C=C1)C(F)(F)F)C1=CC=CC=C1
  • 化学全称
    ——

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Richman A, et al. Epilepsy Res. 2007 Apr;74(1):19-27.
产品手册
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